How "immunomodulatory" are IMIDs?
نویسنده
چکیده
In this issue of Blood, Hsu and colleagues report that the immunostimulatory effect of lenalidomide on natural killer (NK)–cell function is profoundly suppressed by concurrent dexamethasone (Dex) therapy in multiple myeloma (MM) patients. These results could have major implications for the design of clinical trials combining lenalidomide and immunotherapies with the intent to stimulate the anti-MM activity of the latter.
منابع مشابه
In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
BACKGROUND Thalidomide and its analogs, lenalidomide and pomalidomide (referred to as immunomodulatory imide drugs or IMiDs) have been known to treat multiple myeloma and other hematologic malignancies as well as to cause teratogenicity. Recently the protein cereblon was identified as the primary target of IMiDs, and crystallographic studies of the cereblon-IMiDs complex showed strong enantiose...
متن کاملImmunomodulatory compounds (IMiDs) in the treatment of multiple myeloma.
The design of innovative, more effective, less toxic therapy of multiple myeloma (MM) is emerging in parallel to a better understanding of the underlying pathophysiology of this common hematologic malignancy. Thalidomide has changed the treatment paradigm of patients with MM. Its efficacy, however, has been compromised by significant side effects. IMiDs (immunodulatory compounds) are structural...
متن کاملNovel Mechanisms of Action for Immunomodulatory Drugs Against Multiple Myeloma : from a Tragedy to a Therapy
Thalidomide, a sedative to ease morning sickness in pregnant women, was banned more than a half century ago due to causing a severe birth defect known as phocomelia. However, the late discovery of its immunomodulatory properties have led to a new era in the treatment of Multiple Myeloma (MM), a fatal disease that back then had no effective therapy available. The recent development and FDA-accel...
متن کاملImmunomodulatory drugs and their therapeutic effect in hematological malignancies through cereblon
Immunomodulatory drugs (IMiDs), today also known as cereblon (CRBN) binding drugs, are therapeutically important anti-cancer and anti-inflammatory drugs. IMiDs are analogs of their prototype compound thalidomide. IMiDs have immune-modulation, anti-angiogenic, anti-inflammatory and anti-proliferative effects. CRBN is a component and substrate receptor of the Cullin 4 Ring E3 Ubiquitin Protein Li...
متن کاملImmunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.
The bone marrow (BM) microenvironment consists of extracellular-matrix and the cellular compartment including immune cells. Multiple myeloma (MM) cell and BM accessory cell interaction promotes MM survival via both cell-cell contact and cytokines. Immunomodulatory agents (IMiDs) target not only MM cells, but also MM cell-immune cell interactions and cytokine signaling. Here we examined the in v...
متن کاملMaintenance Therapy with Immunomodulatory Drugs after Autologous Stem Cell Transplantation in Patients with Multiple Myeloma: A Meta-Analysis of Randomized Controlled Trials
BACKGROUND Although high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) has been confirmed to result in longer remission time than conventional chemotherapy, multiple myeloma (MM) remains incurable. Post-ASCT maintenance is considered as a strategy for obtaining durable remissions and preventing tumor progression. Randomized controlled trials (RCTs) studying maintenance the...
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ورودعنوان ژورنال:
- Blood
دوره 117 5 شماره
صفحات -
تاریخ انتشار 2011